We Haven’t Uploaded a Fly Brain — But We Can Finally Test How to Simulate One
In September 2026, researchers published a connectome of the adult male fruit fly containing 166,691 neurons across the brain and ventral nerve cord, linked by roughly 125 million synaptic connections. Google Research describes it as the largest brain map yet produced by number of neurons. Within days, the internet was talking about downloadable fly brains, virtual flies and the beginnings of biological mind uploading. We have not uploaded a fly. What has happened may be more important scientifically: neuroscience is acquiring nervous systems detailed enough that researchers can begin testing, rather than merely speculating about, what a brain simulation actually requires. If we know the wiring in extraordinary detail, how much of the remaining biology must we reproduce before a computational model begins to predict what the real nervous system does? Editorial image generated by the author. A Wiring Diagram Is Not a Brain Upload A connectome is essentially a map...